T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Authors :: Roessner, Philipp M.
Seufert, Isabelle
Chapaprieta, Vicente
Jayabalan, Ruparoshni
Briesch, Hannah
Massoni-Badosa, Ramon
Boskovic, Pavle
Benckendorff, Julian
Roider, Tobias
Arseni, Lavinia
Coelho, Mariana
Chakraborty, Supriya
Vaca, Alicia M.
Sivina, Mariela
Muckenhuber, Markus
Rodriguez-Rodriguez, Sonia
Bonato, Alice
Herbst, Sophie A.
Zapatka, Marc
Sun, Clare
Kretzmer, Helene
Naake, Thomas
Bruch, Peter-Martin
Czernilofsky, Felix
ten Hacken, Elisa
Schneider, Martin
Helm, Dominic
Yosifov, Deyan Y.
Kauer, Joseph
Danilov, Alexey V.
Bewarder, Moritz
Heyne, Kristina
Schneider, Christof
Stilgenbauer, Stephan
Wiestner, Adrian
Mallm, Jan-Philipp
Burger, Jan A.
Efremov, Dimitar G.
Lichter, Peter
Dietrich, Sascha
Martin-Subero, José I.
Rippe, Karsten
Seiffert, Martina
Source :: Blood; August 2024, Vol. 144 Issue: 5 p510-524, 15p
Publication Year :: 2024
Abstract: •T-bet acts as a tumor suppressor by enhancing interferon signaling and suppressing proliferation of malignant B cells.•T-bet expression in CLL cells is positively correlated with longer overall survival in patients with CLL.

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