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Temporal dynamics and genomic programming of plasma cell fates
- Source :
- Nature Immunology; June 2024, Vol. 25 Issue: 6 p1097-1109, 13p
- Publication Year :
- 2024
-
Abstract
- Affinity-matured plasma cells (PCs) of varying lifespans are generated through a germinal center (GC) response. The developmental dynamics and genomic programs of antigen-specific PC precursors remain to be elucidated. Here, using a model antigen in mice, we demonstrate biphasic generation of PC precursors, with those generating long-lived bone marrow PCs preferentially produced in the late phase of GC response. Clonal tracing using single-cell RNA sequencing and B cell antigen receptor sequencing in spleen and bone marrow compartments, coupled with adoptive transfer experiments, reveals a new PC transition state that gives rise to functionally competent PC precursors. The latter undergo clonal expansion, dependent on inducible expression of TIGIT. We propose a model for the proliferation and programming of precursors of long-lived PCs, based on extended antigen encounters in the GC.
Details
- Language :
- English
- ISSN :
- 15292908 and 15292916
- Volume :
- 25
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Nature Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs66240554
- Full Text :
- https://doi.org/10.1038/s41590-024-01831-y