Motive and opportunity: MYCrearrangements in high-grade B-cell lymphoma with MYCand BCL2rearrangements (an LLMPP study)

Authors :: Hilton, Laura K.
Collinge, Brett
Ben-Neriah, Susana
Alduaij, Waleed
Shaalan, Haya
Weng, Andrew P.
Cruz, Manuela
Slack, Graham W.
Farinha, Pedro
Miyata-Takata, Tomoko
Boyle, Merrill
Meissner, Barbara
Cook, James R.
Ondrejka, Sarah L.
Ott, German
Rosenwald, Andreas
Campo, Elias
Amador, Catalina
Greiner, Timothy C.
Raess, Philipp W.
Song, Joo Y.
Inghirami, Giorgio
Jaffe, Elaine S.
Weisenburger, Dennis D.
Chan, Wing C.
Beiske, Klaus
Fu, Kai
Delabie, Jan
Pittaluga, Stefania
Iqbal, Javeed
Wright, George
Sehn, Laurie H.
Savage, Kerry J.
Mungall, Andrew J.
Feldman, Andrew L.
Staudt, Louis M.
Steidl, Christian
Rimsza, Lisa M.
Morin, Ryan D.
Scott, David W.
Source :: Blood; August 2024, Vol. 144 Issue: 5 p525-540, 16p
Publication Year :: 2024
Abstract: •Abundant aberrant somatic hypermutation contributes to the promiscuity of MYCrearrangement partners in HGBCL-DH-BCL2.•MYCrearrangement architecture in HGBCL-DH-BCL2preserves expression of both the B-cell receptor and BCL2 from the preexisting IGH::BCL2.

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