Lipoprotein subclasses are associated with Hepatic steatosis: insights from the prospective multicenter imaging study for the evaluation of chest pain (PROMISE) clinical trial

•The nr1 cause of morbidity and mortality in hepatic steatosis (HS) is CV disease.•Clinically, HS is associated with dyslipidemia and coronary artery disease (CAD).•Lipoprotein particle number/size are associated with CAD and CV events.•We analyzed the association lipoprotein particle size/number and HS on CT/biopsy.•Large TRL, mean sizes of TRL-, and HDL were associated with HS on CT/biopsy.•The use of lipoprotein subclasses may improve CV risk assessment in patients with HS.