Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosisinfection status: a systematic review and individual-participant data meta-analysis of contact tracing studies

Tuberculosis is a preventable disease. However, there is debate regarding which individuals would benefit most from tuberculosis preventive treatment and whether these benefits vary in settings with a high burden and low burden of tuberculosis. We aimed to compare the effectiveness of tuberculosis preventive treatment in exposed individuals of differing ages and Mycobacterium tuberculosisinfection status while considering tuberculosis burden of the settings.