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Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics
- Source :
- CNS Oncology; July 2015, Vol. 4 Issue: 4 p225-234, 10p
- Publication Year :
- 2015
-
Abstract
- SUMMARY Glioblastoma is the most common primary brain tumor in adults and carries a dismal prognosis despite advancements in treatment. Diffuse tumor infiltration precludes curative surgical resection and necessitates advancements in drug delivery mechanisms. Convection-enhanced delivery (CED) enables continuous local drug delivery for a diverse population of antitumor agents. Importantly, CED circumvents therapeutic challenges posed by the blood–brain barrier by facilitating concentrated local therapeutic drug delivery with limited systemic effects. Here, we present a concise review of properties essential for safe and efficient convection-enhanced drug delivery, as well as a focused review of clinical studies evaluating CED in the treatment of glioblastoma.
Details
- Language :
- English
- ISSN :
- 20450907 and 20450915
- Volume :
- 4
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- CNS Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs66442840
- Full Text :
- https://doi.org/10.2217/cns.15.12