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Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle
- Source :
- Blood; August 2024, Vol. 144 Issue: 7 p729-741, 13p
- Publication Year :
- 2024
-
Abstract
- •Substantial attrition of HSC function occurs within 24 hours of ex vivo culture independently of cell cycle progression.•Inhibition of JAK/STAT signaling during culture adaptation via ruxolitinib improves HSC function ex vivo.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 144
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs66519610
- Full Text :
- https://doi.org/10.1182/blood.2023021426