Isolation and Bioactivities of StemonaAlkaloid: A Review

Objective/Background:In Chinese, Vietnamese, and Thai traditional medicine of Southeast Asian countries, Stemonaceaeplants have long been employed. Various studies have proved that these herbal plants contain Stemonaalkaloids with valuable medicinal value. Although some review articles on Stemonaalkaloids have appeared in the literature, they are quite outdated. The current study offers a comprehensive review of the isolation and bioactivities of Stemonaalkaloids. The article might be useful for chemists who work in alkaloid chemistry as well as pharmaceutical areas. Methods:“Stemonaalkaloids” was the most useful keyword to search for literature data. References have been collected from various resources such as Google Scholar, SciFinder, and PubMed. More than 120 electronic publications were obtained from these resources. Results:More than 250 Stemonaalkaloids from 8 groups have been isolated and structurally elucidated from Stemonaceaeplants. Extracts from these plants as well as isolated compounds possess a wide range of bioactivities, such as antituberculosis, antibacterial, antifungal, and antihelmintic properties activities. Conclusion:In this review article, we have summarized 116 studies on the isolation and bioactivities of Stemonaalkaloids in the literature. More than 250 Stemonaalkaloid compounds have been isolated and identified. In addition, the article also gives an overview of the bioactivities of Stemonaalkaloids.