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A Clinicopathological Study of Oesophageal Malignancies With Special Reference to Immunohistochemical Expression of HER2/Neu
- Source :
- Apollo Medicine; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- Background and Aims: Oesophageal malignancies tend to have poor prognosis and thus there is a need to identify newer therapeutic targets for their treatment. This study aimed at studying the incidence and histopathological spectrum of oesophageal malignancies with special emphasis on immunohistochemical expression of HER2/Neu in adenocarcinomas.Material and Methods: This study was a retrospective descriptive study conducted in a tertiary care centre in South India. Endoscopic biopsies and resection specimens of oesophageal malignancies were included in the study. Immunohistochemical analysis for HER2/Neu was performed on all oesophageal adenocarcinomas.Results: Squamous cell carcinoma constituted the most common malignancy in this study. Approximately 20% of oesophageal adenocarcinomas showed positivity for HER2/Neu. A prominent association of Barrett’s metaplasia with oesophageal adenocarcinoma was noted.
Details
- Language :
- English
- ISSN :
- 09760016 and 22133682
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Apollo Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs66591898
- Full Text :
- https://doi.org/10.1177/09760016241258043