Efficient and environmentally friendly uric acid voltametric sensor based on Ni-MOF and Carboxylated multi-walled carbon nanotubes nanocomposites

Uric acid (UA) levels are significant in the monitoring of human health, making their detection very important. In this paper, a simple and innovative electrochemical method for the detecting UA was established, using a sensing platform based on hybrid electrodes of Nickel-Metal Organic Framework (Ni-MOF) and carboxylated multi-walled carbon nanotubes (MWCNTs-COOH). Detailed investigations into the electrocatalytic activity of Ni-MOF/MWCNTs-COOH/GCE for The Ni-MOF/MWCNTs-COOH exhibited remarkable catalytic activity for UA oxidation. The detection limit was 0.005μM, with a sensitivity calculation result of 6.377µAµM-1, and a wide linearity interval (0.03 - 10μM, 10 - 300μM). Utilizing its high sensitivity and selectivity, this sensor was used for the measurement of UA in biological fluids, including human serum and urine samples, recovery amounts being 96.6 - 100.8%, and 98.9 - 101.3%. This work is highly significant; offering new perspectives for the application of Ni-MOF based chemical sensors in the realms of environmental monitoring and healthcare.