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Adenovirus infections after allogeneic hematopoietic cell transplantation in children and adults: a study from the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
- Source :
- Bone Marrow Transplantation; 20240101, Issue: Preprints p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- The objective of the study was the analysis of clinical types, outcomes, and risk factors associated with the outcome of adenovirus (ADV) infection, in children and adults after allo-HCT. A total number of 2529 patients (43.9% children; 56.1% adults) transplanted between 2000 and 2022 reported to the EBMT database with diagnosis of ADV infection were analyzed. ADV infection manifested mainly as viremia (62.6%) or gastrointestinal infection (17.9%). The risk of 1-year mortality was higher in adults (p= 0.0001), and in patients with ADV infection developing before day +100 (p< 0.0001). The 100-day overall survival after diagnosis of ADV infections was 79.2% in children and 71.9% in adults (p< 0.0001). Factors contributing to increased risk of death by day +100 in multivariate analysis, in children: CMV seropositivity of donor and/or recipient (p= 0.02), and Lansky/Karnofsky score <90 (p< 0.0001), while in adults: type of ADV infection (viremia or pneumonia vs gastrointestinal infection) (p= 0.0004), second or higher HCT (p= 0.0003), and shorter time from allo-HCT to ADV infection (p= 0.003). In conclusion, we have shown that in patients infected with ADV, short-term survival is better in children than adults. Factors directly related to ADV infection (time, clinical type) contribute to mortality in adults, while pre-transplant factors (CMV serostatus, Lansky/Karnofsky score) contribute to mortality in children.
Details
- Language :
- English
- ISSN :
- 02683369 and 14765365
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Bone Marrow Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs66887969
- Full Text :
- https://doi.org/10.1038/s41409-024-02361-9