Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity

Transcriptionally defined small cell lung cancer (SCLC) subtypes represent dynamic cell states rather than static phenotypes.Subtype conversions appear to most commonly favor transition from high-neuroendocrine to low- or non-neuroendocrine states and are implicated in chemoresistance.While an inflamed phenotype is associated with low- or non-neuroendocrine status, the determinants of response to immunotherapy in SCLC remain an area of controversy.