Back to Search
Start Over
Mechanistic Studies on Rh(III)-Catalyzed Defluorinative Annulation of N-Sulfonylarylamides with Ethyl 2-Diazo-3,3,3-Trifluoropropanoates
- Source :
- Organometallics; September 2024, Vol. 43 Issue: 17 p1861-1868, 8p
- Publication Year :
- 2024
-
Abstract
- The synthesis of fluorinated isoquinoline derivatives holds significant value in organic synthesis and medicine. Research into the reaction mechanisms and possible pathways for synthesizing these compounds plays a crucial role in advancing the development and applications of isoquinoline derivatives. Using density functional theory methods, we explored the reaction mechanism and potential pathways of the Rh(III)-catalyzed defluorinative annulation of N-sulfonylarylamides with ethyl 2-diazo-3,3,3-trifluoropropanoates. Theoretical calculations indicate that the reaction initiates with the formation of a metal carbene via C–H activation and denitrogenation, followed by migratory insertion. Subsequent steps involve metal-assisted β-fluoride elimination and anion exchange. Finally, intramolecular cyclization, defluorination, and sulfonyl migration yield isoquinoline products.
Details
- Language :
- English
- ISSN :
- 02767333 and 15206041
- Volume :
- 43
- Issue :
- 17
- Database :
- Supplemental Index
- Journal :
- Organometallics
- Publication Type :
- Periodical
- Accession number :
- ejs67132599
- Full Text :
- https://doi.org/10.1021/acs.organomet.4c00249