Predictors of six-month change in health-related quality of life in people with multiple sclerosis: A secondary data analysis of a randomized controlled trial

•Predictors of six-month change in physical and mental HRQoL were investigated.•Predictors were assessed at clinic entry for a three-week rehabilitation stay.•Physical HRQoL and depressive mood predicted six-month change in physical HRQoL.•Mental HRQoL and time since diagnosis predicted six-month change in mental HRQoL.•The regression models explained 18.6 % (physical) and 26.8 % (mental) of the variance.