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Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
Authors :
Deanfield, John Verma, Subodh Scirica, Benjamin M Kahn, Steven E Emerson, Scott S Ryan, Donna Lingvay, Ildiko Colhoun, Helen M Plutzky, Jorge Kosiborod, Mikhail N Hovingh, G Kees Hardt-Lindberg, Søren Frenkel, Ofir Weeke, Peter E Rasmussen, Søren Goudev, Assen Lang, Chim C Urina-Triana, Miguel Pietilä, Mikko Lincoff, A Michael Abe, Mitsunori Abhaichand, Rajpal K Abhayaratna, Walter P Abhyankar, Atul Abidin, Imran B Zainal Abou Assi, Hiba Accini Mendoza, Jose L Adas, Mine Agaiby, John M Agarwal, Devendra K Agha, Maher Ahmed, Azazuddin Ahtiainen, Petteri Aigner, Elmar Ajay, Naik Ali, Norsiah Al-Karadsheh, Amer Allison, Roy Allison, Dale C Alpenidze, Diana Altuntas, Yuksel Al-Zoebi, Ayham Ambuj, Roy Amerena, John Anderson, Robert J Ando, Toshiaki Andrews, Robert Antonova, Elizaveta Appel, Karl-Friedrich Arantes, Flávia B Araz, Mustafa Arbel, Yaron Arenas León, José L Argyrakopoulou, Georgia Ariani, Mehrdad Arias Mendoza, Maria A Arif, Ahmed A Arneja, Jaspal Aroda, Vanita R Aronne, Louis J Arstall, Margaret Asamoah, Njaimeh Asanin, Milika Audish, Hanid Avram, Rodica Badat, Aysha Badiu, Corin V Bakdash, Wa'el Bakiner, Okan S Bandezi, Vuyokazi N Bang, Liew H Bansal, Sandeep Baranyai, Marietta Barbarash, Olga Barber, Mark Barnum, Otis Barone Rochette, Gilles Bashkin, Amir Baum, Seth Bays, Harold E Bazzoni Ruiz, Alberto E Beckowski, Maciej Beerachee, Yaswin Bellary, Srikanth Belousova, Lidia Berk, Martin Bernstein, Marc Berra, Cesare Beshay, Isaac Bhagwat, Ajit Bhan, Arti Biggs, William C Billings, Liana Bitar, Fahed Block, Bradley Bo, Simona Bogdanski, Pawel Bolshakova, Olga O Boshchenko, Alla A Bosworth, Hayden Botero Lopez, Rodrigo Bôttcher, Morten Bourgeois, Ronald Brautigam, Donald Breton, Cristian F Broadley, Andrew Brockmyre, Andrew P Brodie, Steven K Bucci, Marco Budincevic, Hrvoje Budoff, Matthew J Buffman, Barry Buljubasic, Nediljka Buranapin, Supawan Burgess, Lesley Burguera, Bartolomé Buriakovska, Olena Buscemi, Silvio Busch, Robert Buse, John B Buynak, Robert Byrne, Maria Caceaune, Elena Cadena Bonfanti, Alberto J Calinescu, Cornell V Call, Robert S Canecki Varzic, Silvija Cannon, Kevin Capehorn, Matt Cariou, Bertrand Carr, Jeffrey Carrillo-Jimenez, Rodolfo Casas, Marcelo Castro, Almudena Celik, Ahmet Cercato, Cintia Cermak, Ondrej Cha, James Y Chacon, Carolina Chaicha-Brom, Tira Chandra, Sandeep Chettibi, Mohamed Chevts, Julia Christopher, Johann Chrustowski, Witold Cif, Adriana Clark, Rebecca Clark, Wayne Clifford, Piers Coetzee, Kathleen Cogni, Giulia Colao, Anna Maria Colquhoun, David M Concha, Mauricio Condit, Jonathan Constance, Christian Constantin, Ciprian Constantinescu, Silviana Corbett, Clive Cornett, George M Correia, Marcelo Cortinovis, Fiorenzo Cosma, Dana Creely, Steven Cross, David Curtis, Brian Czochra, Wojciech Daboul, Nizar Y Dagdelen, Selcuk D'agostino, Ronald Dang, Cuong Datta, Sudip Davuluri, Ashwini K Dawood, Saleem Y De Jong, Douwe M De La Cuesta, Carmen De Los Rios Ibarra, Manuel O De Pablo, Carmen De Pauw, Michel Dela Llana, Alexander Delibasic, Maja Delic-Brkljacic, Diana Demicheli, Thibaud Denger, Ralf J Desai, Devang Desai, Piyush Desouza, Cyrus V Dicker, Dror Djenic, Nemanja Dobson, Simon Doi, Masayuki Doran, Jesse A Dorman, Reinhart Dotta, Francesco Dukes, Carl E Duronto, Ernesto Durst, Ronen Dvoryashina, Irina V Ebrahim, Iftikhar O Eggebrecht, Holger Egstrup, Kenneth Ekinci, Elif I Eliasson, Björn Eliasson, Ken Enache, Georgiana Enculescu, Dan English, Patrick Ermakova, Polina Ershova, Olga Ezaki, Hirotaka Ezhov, Marat Farias, Eduardo Farias, Javier M Farsky, Pedro S Ferreira, Daniel Filteau, Pierre Finneran, Matthew P Folkens, Eric M Fonseca, Alberto G Fonseca, Luisa Fordan, Steven Fourie, Nyda França, Sara Franco, Denise R Franek, Edward Friedman, Keith Frittitta, Lucia Froer, Michael Fuckar, Krunoslav Fujii, Kenshi Fujita, Ryoko Fukushima, Yasushi Fulat, Mohamed Fulwani, Mahesh Gajos, Grzegorz Galyavich, Albert Gambill, Michael L Gandotra, Dheeraj Winston, Gandy Garcia Hernandez, Pedro A García Reza, Raymundo Garg, Naveen Garg, Sandeep Garvey, William T Garza, Juan C Gatta-Cherifi, Blandine Gelev, Valeri Geller, Steven A Geohas, Jeffrey G Georgiev, Borislav Ghazi, Adline Gilbert, Matthew P Gilinskaya, Olga Gislason, Gunnar Gogas Yavuz, Dilek González Albarrán, Olga Gordeev, Ivan G Gorton, Sidney C Goudev, Assen Gretland Valderhaug, Tone Groenemeijer, Bjorn Gul, Ibrahim Gullestad, Lars Gurieva, Irina Guseva, Galina N Hagenow, Andreas Haluzik, Martin Halvorsen, Sigrun Hammoudi, Naima Hanaoka, Keiichi Hancu, Nicolae Hanusch, Ursula Harris, Kathleen Harris, Barry Hartleib, Michael Hartman, Aaron N Hata, Yoshiki Heimer, Brian Herman, Lee Herzog, William Hewitt, Eric Heymer, Peter Hiremath, Shirish Hjelmesaeth, Joeran Høgalmen, Rasmus Geir Høivik, Hans Olav Holmer, Helene Horoshko, Olha Houser, Patricia M Hove, Jens D Hsieh, I-Chang Hulot, Jean-Sébastien Hussein, Zanariah Ilashchuk, Tetiana Ilveskoski, Erkki Ipatko, Irina Iranmanesh, Ali Isawa, Tsuyoshi Issa, Moises Iteld, Bruce Iwasawa, Takamasa Jabbar, Danish Jackson, Richard A Jackson-Voyzey, Ewart Jacob, Stephan Jaffrani, Naseem A Jardula, Michael F Jastreboff, Ania Jensen, Svend E Jerkins, Terri Jimenez-Ramos, Silvia A Jitendra Pal Singh, Sawhney Johnson, Wallace Joyce, John M Jozefowska, Malgorzata Jugnundan, Prakash Jungmair, Wolfgang Jurowiecki, Jaroslaw Kadokami, Toshiaki Kahali, Dhiman Kahrmann, Gerd Kaiser, Sergio E Kalmucki, Piotr Kanadasi, Mehmet Kandath, David Kania, Grzegorz Kannan, J Kapp, Cornelia Karczmarczyk, Agnieszka Kartalis, Athanasios Kaser, Susanne Kasim, Sazzli Shahlan Kastelic, Richard Kato, Toshiaki Katova, Tzvetana Kaul, Upendra Kautzky-Willer, Alexandra Kawanishi, Masahiro Kayikcioglu, Meral Kazakova, Elena E Keeling, Philip Kempe, Hans-Peter Kereiakes, Dean J Kerneis, Mathieu Keski-Opas, Tiina Khadra, Suhail Khaisheva, Larisa Kharakhulakh, Marina Khlevchuk, Tatiana Khoo, Jeffrey Kiatchoosakun, Songsak Kinoshita, Noriyuki Kinoshita, Masaharu Kitamura, Ryoji Kiyosue, Arihiro Klavina, Irina Klein, Eric J Klimsa, Zdenek Klonoff, David Klug, Eric Kobalava, Zhanna Kodera, Satoshi Koga, Tokushi Kokkinos, Alexander Koleckar, Pavel Könyves, László Koren, Michael J Kormann, Adrian P Kostner, Karam Kreutzmann, Kristin Krishinan, Saravanan Krishnasamy, Sathya S Krivosheeva, Inga Kruljac, Ivan Kubicki, Ted Kuchar, Ladislav Kujawiak, Monika Kunishige, Hideyuki Kurtinecz, Melinda Kurtz Lisboa, Hugo R Kushnir, Mykola Kyyak, Yulian Lace, Arija Lakka, Timo Lalic, Nebojsa Lalic, Katarina Lambadiari, Vaia Lanaras, Leonidas Lang, Chim Langlois, Marie-France Lash, Joseph Latkovskis, Gustavs Lau, David Lazcano Soto, José Roberto Le Roux, Carel Ledesma, Gilbert N Lee, Li Yuan Lee, Thung-Lip Lee, Kelvin Lehrke, Michael Leite, Silmara O Leksycka, Agata Lenzmeier, Thomas Leonetti, Frida Leonidova, Viktoriia Lepor, Norman Leung, Melissa Levchenko, Olena Levins, Peter Levy, Louis J Lewis, Matthew Liberopoulos, Evangelos Liberty, Idit Lindholm, Carl-Johan Lingvay, Ildiko Linhart, Ales Liu, Ming-En Liu, Jenny Lofton, Holly Logemann, Timothy Lombaard, Johannes J Lombard, Landman Lorraine, Richard Lovell, Charles F Ludvik, Bernhard Lukaszewicz, Monika Lupkovics, Géza Lupovitch, Steven Lupu, Sirona Lynch, Mary Lysak, Zoreslava Lysenko, Tatyana A Maeda, Hajime Maeda, Itaru Mæng, Michael Mahajan, Ajay U Maher, Vincent Maia, Lilia N Makotoko, Ellen M Malavazos, Alexis Malecha, Jan Malicherova, Emilia Manita, Mamoru Mannucci, Edoardo Mareev, Viacheslav Marin, Liliana Markova, Tatiana Marso, Steven P Martens, F.M.A.C. Martinez, Cuper Martinez Cano, Carlos A Martins, Cristina Masmiquel Comas, Luis Matsumoto, Takashi Mcdonald, Kenneth Mcgowan, Barbara Mcgrew, Frank Mclean, Barry K Mcpherson, David D Merino Torres, Juan Francisco Meyers, Peter Meyhöfer, Sebastian Mezquita Raya, Pedro Milanova, Maria Milicic, Davor Miller, Gary Mills, Richard E Mîndrescu, Nicoleta M Mingrone, Geltrude Minkova, Dotska A Mirani, Marco Miras, Alexander Mistodie, Cristina V Mitomo, Satoru Mittal, Sanjay Miyake, Taiji Miyamoto, Naomasa Molony, David Monteiro, Pedro Mooe, Thomas Moosa, Naeem Morales Portillo, Cristobal Morales Villegas, Enrique C Morawski, Emily J Morbey, Claire Morin, Robert P Morisaki, Kuniaki Morosanu, Magdalena Mosenzon, Ofri Mostovoy, Yuriy Munir, Iqbal Muratori, Fabrizio Murray, Ryan Murthy, Avinash Myint, Min Myshanych, Galyna Nafornita, Valerica Nagano, Takuya Nair, Sunil Nakhle, Samer N Natsuaki, Masahiro Nayak, Bindu M Nibouche, Djamel Eddine Nicholls, Stephen Nicolau, José C Nicolescu, Georgiana Nierop, Peter Niskanen, Leo Ntaios, George Nygård, Ottar Kjell Oaks, Joshua B Obrezan, Andrey O'donnell, Philip Oguri, Mitsutoshi Oguzhan, Abdurrahman Oh, Fumiki Ohsugi, Mitsuru Okada, Yoshio Okayama, Hideki Onaca, Adriana Onaka, Haruhiko Oneil, Patrick Ong, Tiong Kiam Ong, Stephen Ono, Yasuhiro Opsahl, Paul J Ostrowska, Lucyna Oviedo, Alejandra Ozdogan, Oner Ozpelit, Ebru Pagkalos, Emmanouil Pagotto, Uberto Páll, Dénes Pandey, Amritanshu- Shekhar Parkhomenko, Oleksandr Parvathareddy, Krishna Malakondareddy Patel, Minesh B Patsilinakos, Sotirios Paul, Neil Pedersen, Sue Pereira, Isabel Pereira, Edward Scott Perez Terns, Paula Perez-Vargas, Elba A Pergaeva, Yulia Perkelvald, Alexander Peskov, Andrey B Peter, Jonathan Peters, Karina Petit, Catherine Petrov, Ivo Philis-Tsimikas, Athena Pietilä, Mikko Pinto, Fausto Piros, Annamária Piyayotai, Dilok Platonov, Dmitriy Poirier, Paul Pop, Lavinia Popa, Bogdan Pop-Busui, Rodica Poremba, John Porto, Alejandro Postadzhiyan, Arman Pothineni, Ramesh B Potu, Ranganatha P Powell, Talessa Prafulla, Kerkar G Prager, Rudolf Prakova-Teneva, Zhulieta R Pratley, Richard E Price, Hermione Pulka, Grazyna Pullman, John Punt, Zelda E Purighalla, Raman S Purnell, Peter Qureshi, Mansoor Rabasa-Lhoret, Remi Raikhel, Marina A Rancane, Gita Randeva, Harpal Rasouli, Neda Reurean Pintilei, Delia V Reyes, Ciro R Rezgale, Inga Rice, Eva Riley, Thaddeus H Risser, Joseph A Ristic, Arsen Rivas Fernández, Margarita Robbins, David Robitaille, Yves Rodbard, Helena W Rodriguez Plazas, Jaime A Römer, T.J. Rosen, Glenn Rosman, Dr Azhari Rossi, Paulo Rudenko, Leonid Ruffin, Omari Ruhani, Anwar Irawan Runev, Nikolay Ruyatkin, Dmitriy Ruzic, Alen Ryabov, Vyacheslav V Rydén, Lars Saggar, Suraj Sakamoto, Tomohiro Salter, Tim Samal, Aditya K Samoilova, Yulia Sanabria, Hugo D Sancak, Seda Sangrigoli, Renee Sansanayudh, Nakarin Santini, Ferruccio Saraiva, José F Sardinov, Ruslan Sargeant, William Sari, Ramazan Sathananthan, Airani Sathyapalan, Thozhukat Sato, Atsushi Sauter, Joachim Sbraccia, Paolo Schaap, J. Schaum, Thomas Schiele, François Scott, John Segal Lieberman, Gabriella Segner, Alexander Senior, Roxy Sergeeva-Kondrachenko, Marina Y Serota, Harvey Serusclat, Pierre Sethi, Rishi Shah, Manoj K Shah, Neerav Shalaev, Sergey Sharma, Raj Sharma, Sumeet Shaydyuk, Oksana Shea, Heidi C Shechter, Michael Shehadeh, Naim Shirazi, Mitra Shlesinger, Yshay Shneker, Ayham Shutemova, Elena Siasos, Gerasimos Siddiqui, Imran A Sidey, Jennifer Sigal, Felix Sime, Iveta Singh, Narendra Siraj, Elias Sivalingam, Kanagaratnam Skoczylas, Grzegorz Smith, Stephen K Smolenskaya, Olga Snyder, Brian Sofer, Yael Sofley, C.W. Solano, Royce Sonmez, Yusuf A Sorokin, Maxim Soto González, Alfonso Sotolongo, Carlos Soufer, Joseph Soyluk Selcukbiricik, Ozlem Spaic, Tamara Spriggs, Douglas Sreenan, Seamus Stahl, Hans-Detlev Stamatelopoulos, Kimon Stanislavchuk, Mykola Stankovic, Goran Stasek, Josef Steg, Gabriel Steindorf, Joerg Stephan, Dominique Stewart, John Still, Christopher St-Maurice, Francois Stogowska-Nikiciuk, Barbara Stoker, Jeff Stokic, Edita Strzelecka, Anna Sturm, Kerstin Sueyoshi, Atsushi Sugiura, Toshiyuki Sultan, Senan Suplotova, Lyudmila A Suwanagool, Arisara Suwanwalaikorn, Sompongse Sveklina, Tatiana Swanson, Neil Swart, Henk Swenson, Bradley P Szyprowska, Ewa Tait, Graeme Takács, Róbert Takeuchi, Yuzo Tamirisa, Aparna Tanaka, Hideki Tatovic, Danijela Tellier, Guy Teragawa, Hiroki Teterovska, Dace Thomas, Nihal Thuan, Jean-Francois Tinahones, Francisco Tisheva-Gospodinova, Snezhanka Toarba, Cristina Todoriuk, Liudmyla Tokmakova, Mariya Tonstad, Serena Toplak, Hermann Tran, Henry Tripathy, Devjit Trusau, Aliaksandr Tsabedze, Nqoba Tsougos, Elias Tsoukas, George M Tuccinardi, Dario Tuna, Mazhar M Turatti, Luiz A Tziomalos, Konstantinos Udommongkol, Chesda Ueda, Osamu Ukkola, Olavi Unubol, Mustafa Urbach, Dorothea Urina Triana, Miguel A Usdan, Lisa Vaidya, Bijay Vale, Noah Vallieres, Gerald Van Beek, Andre P Van De Borne, Philippe Van Der Walt, Eugene Van Der Zwaan, C. Van Nieuwenhuizen, Elane Van Zyl, Louis Vanduynhoven, Philippe Varghese, Kiron Vasileva, Svetla P Vassilev, Dobrin Vathesatogkit, Prin Velychko, Valentyna Vercammen, Chris Verges, Bruno Verma, Subodh Verwerft, Jan Vesela, Alica Veselovskaya, Nadezhda G Vettor, Roberto Veze, Irina Vijan, Vinod Vijayaraghavan, Ram Villarino, Adriana Vincent, Royce Vinogradova, Oksana Vishlitzky, Victor Vlad, Adrian Vladu, Ionela Mihaela Vo, Anthony Von Engelhardt, Charlotte Von Münchhausen, Candy Vorobyeva, Olga Vossenberg, T. Vrolix, Mathias Vukicevic, Marjana Vyshnyvetskyy, Ivan Wadvalla, Shahid Wagner, Jan Wakeling, John Wallace, James Wan Mohamed, Wan Mohd Izani Wander, Gurpreet S Ward, Kathleen Warren, Mark L Watanabe, Atsuyuki Weber, Bruce Weintraub, Howard Weisnagel, John Welker, James Wendisch, Ulrich Wenocur, Howard S Wierum, Craig Wilding, John William, Maged Wilson, Pete Wilson, Jonathan P Wong, Yuk-Ki Wongcharoen, Wanwarang Wozniak, Iwona Wu, Chau-Chung Wyatt, Nell Wynne, Alan Yamaguchi, Hiroshi Yamasaki, Masahiro Yazici, Dilek Yeh, Hung-I Yotov, Yoto Yuan, Qingyang Zacher, Jeffrey Zagrebelnaya, Olga Zaidman, Cesar J Zalevskaya, Alsu Zarich, Stuart Zatelli, Maria Chiara Zeller, Helga Zhdanova, Elena A Zornitzki, Taiba Zrazhevskiy, Konstantin Zykov, Mikhail Lincoff, A Michael Ryan, Donna H Colhoun, Helen M Deanfield, John E Emerson, Scott S Kahn, Steven E Kushner, Robert F Plutzky, Jorge Brown-Frandsen, Kirstine Hovingh, G Kees Hardt-Lindberg, Soren Tornøe, Christoffer W
Source :
The Lancet; August 2024, Vol. 404 Issue: 10454 p773-786, 14p
Publication Year :
2024
Abstract
Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse cardiovascular events (MACE) in people with overweight or obesity, but the effects of this drug on outcomes in patients with atherosclerotic cardiovascular disease and heart failure are unknown. We report a prespecified analysis of the effect of once-weekly subcutaneous semaglutide 2·4 mg on ischaemic and heart failure cardiovascular outcomes. We aimed to investigate if semaglutide was beneficial in patients with atherosclerotic cardiovascular disease with a history of heart failure compared with placebo; if there was a difference in outcome in patients designated as having heart failure with preserved ejection fraction compared with heart failure with reduced ejection fraction; and if the efficacy and safety of semaglutide in patients with heart failure was related to baseline characteristics or subtype of heart failure.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
404
Issue :
10454
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs67213204
Full Text :
https://doi.org/10.1016/S0140-6736(24)01498-3