Semiheterogeneous Photoredox Catalysis: Synthesis of 3-Sulfonylquinolines via Radical Multicomponent Cascade Annulation

An efficient photocatalytic protocol combining heterogeneous semiconductors as photocatalysts and NHPI as a redox reagent was disclosed. Under this protocol, 3-sulfonylquinolines were formed in up to 92% yield via a multicomponent radical cascade annulation. Good substituent tolerance and gram-scale reaction showed the potential in fine chemicals modification and pharmaceutical synthesis.