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Cascade Cyclization of N-Cyanamide Alkenes for the Divergent Synthesis of Azido-, Nitro-, and Alkenyl-Containing Pyrroloquinazolinones
- Source :
- Organic Letters; September 2024, Vol. 26 Issue: 38 p8028-8033, 6p
- Publication Year :
- 2024
-
Abstract
- Radical cascade cyclizations of N-cyanamide alkenes have been developed for the divergent synthesis of pyrroloquinazolinones bearing azido, alkenyl, and nitro groups by controlling the reaction conditions. The reaction temperature and the loading of the base play important roles in the different reaction pathways. These reactions are characterized by wide functional group compatibility and mild conditions.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 26
- Issue :
- 38
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs67405268
- Full Text :
- https://doi.org/10.1021/acs.orglett.4c02803