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Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia

Authors :
Vijenthira, Abi
Volpe, Virginia O.
Sekar, Aswin
Santos Azevedo, Roberta
Mikhaleva, Mariia
Gibson, Christopher J.
Martindale, Stephen P.
Fardoun, Rayan
Tyekucheva, Svitlana
Ren, Yue
Fernandes, Stacey M.
Knisbacher, Binyamin A.
Hahn, Cynthia K.
Getz, Gad
Wu, Catherine J.
Davids, Matthew S.
Brown, Jennifer R.
Source :
Blood Advances; December 2024, Vol. 8 Issue: 23 p5949-5956, 8p
Publication Year :
2024

Abstract

•The prevalence of myeloid CHIP in patients with CLL was 12% in untreated and 24% in treated patients (85% with prior chemotherapy exposure).•The presence of ≥2 M-CHIP mutations was associated with survival, even accounting for prior treatment and age.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
8
Issue :
23
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs67493986
Full Text :
https://doi.org/10.1182/bloodadvances.2024013414