Isavuconazole off-label use as an empirical treatment of invasive fungal infections

•Isavuconazole off-labelled use as an empirical therapy.•Prescription review to study this clinical practice.•Good mycological efficacy and hepatic safety of empirical isavuconazole.•Early reevaluation of isavuconazole to maximise the safety profile.•Isavuconazole therapeutic drug monitoring to ensure an optimal exposure.