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Polysaccharide-Based Injectable Hydrogel Loaded with Quercetin Promotes Scarless Healing of Burn Wounds by Reducing Inflammation

Authors :
Xing, Dandan
Du, Yangrui
Dai, Kang
Lang, Shiying
Bai, Yangjing
Liu, Gongyan
Source :
Biomacromolecules; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

Moisture loss, infection, and severe inflammatory reactions are the primary factors affecting burn wound healing and leading to scar formation. Herein, we developed a quercetin-loaded polysaccharide-based injectable hydrogel (named PECE). The PECE consists of oxidized sodium alginate (OAlg) coupled with chitosan (CS) via Schiff bases and electrostatic interactions, while Que is incorporated via hydrogen bonding. Benefiting from the hydroxyl and carboxyl groups, PECE features distinguished moisturizing ability. Additionally, the sustained release of Que imparts remarkable antibacterial activity against Escherichia coliand Staphylococcus aureus. Likewise, PECE demonstrates favorable in vitroanti-inflammatory capacity as released Que significantly downregulates pro-inflammatory factors (IL-6 and TNF-α) secreted by RAW 264.7 macrophages. More importantly, in a rat model of deep second-degree burn wounds, PECE effectively inhibits wound infection, reduces inflammation, and promotes angiogenesis and collagen deposition, ultimately minimizing scar formation. Overall, this work presents a promising strategy for scarless healing of burn wounds.

Details

Language :
English
ISSN :
15257797 and 15264602
Issue :
Preprints
Database :
Supplemental Index
Journal :
Biomacromolecules
Publication Type :
Periodical
Accession number :
ejs67831608
Full Text :
https://doi.org/10.1021/acs.biomac.4c01276