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Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy

Authors :
Pezzini, Alessandro
Tarantino, Barbara
Zedde, Maria Luisa
Marcheselli, Simona
Silvestrelli, Giorgio
Ciccone, Alfonso
Delodovici, Maria Luisa
Princiotta Cariddi, Lucia
Vidale, Simone
Paciaroni, Maurizio
Azzini, Cristiano
Padroni, Marina
Gamba, Massimo
Magoni, Mauro
Del Sette, Massimo
Tassi, Rossana
de Franco, Ivo Giuseppe
Cavallini, Anna
Calabrò, Rocco Salvatore
Cappellari, Manuel
Giorli, Elisa
Giacalone, Giacomo
Lodigiani, Corrado
Zenorini, Mara
Valletta, Francesco
Pascarella, Rosario
Abrignani, Giorgia
Castellini, Paola
Genovese, Antonio
Latte, Lilia
Trapasso, Maria Claudia
Grisendi, Ilaria
Assenza, Federica
Napoli, Manuela
Moratti, Claudio
Beccattini, Sofia
Acampa, Maurizio
Valzania, Franco
Grassi, Mario
Gentilini, Davide
Source :
Journal of Neurology, Neurosurgery, & Psychiatry (JNNP); 2025, Vol. 96 Issue: 1 p95-99, 5p
Publication Year :
2025

Abstract

BackgroundWhether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.MethodsIn the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.Results1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).ConclusionsStatin use appears to be unrelated to the risk of ICH recurrence.

Details

Language :
English
ISSN :
00223050 and 1468330X
Volume :
96
Issue :
1
Database :
Supplemental Index
Journal :
Journal of Neurology, Neurosurgery, & Psychiatry (JNNP)
Publication Type :
Periodical
Accession number :
ejs68307028
Full Text :
https://doi.org/10.1136/jnnp-2024-333396