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Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Authors :
Rubin, David T
Allegretti, Jessica R
Panés, Julián
Shipitofsky, Nicole
Yarandi, Shadi S
Huang, Kuan-Hsiang Gary
Germinaro, Matthew
Wilson, Rebbecca
Zhang, Hongyan
Johanns, Jewel
Feagan, Brian G
Hisamatsu, Tadakazu
Lichtenstein, Gary R
Bressler, Brian
Peyrin-Biroulet, Laurent
Sands, Bruce E
Dignass, Axel
Abrahamovych, Orest
Abu-farsakh, Niazy
Afanasieva, Halyna
Akpinar, Hale
Al Kharrat, Houssam
Altintas, Engin
Altwegg, Romain
Andreev, Pavel
Aomatsu, Kazuki
Araki, Hiroshi
Argollo, Marjorie
Ariel, Federico
Armuzzi, Alessandro
Ashida, Toshifumi
Augustyn, Monika
Aumais, Guy
Azum, Martín
Baert, Filip
Balaz, Jozef
Balderramo, Domingo
Begun, Jakob
Berova, Temenuzhka
Billiauws, Lore
Blanco, Antonio
Bortlik, Martin
Bossa, Fabrizio
Bunkova, Elena
Cabello, Mercedes
Cao, Qian
Caprioli, Flavio
Cerqueira, Rute
Chachu, Karen
Chamouard, Patrick
Chen, Chunxiao
Chen, Yan
Chen, Baili
Chen, Dongfeng
Chen, Hong
Chen, Youxiang
Chen, Chou-chen
Cheon, Jaehee
Chen, Minhu
Chiu, Cheng-tang
Choi, Changhwan
Chow, Elizabeth
Cicala, Michele
Cintra, Aderson
Danilkiewicz, Wit
Datsenko, Olena
De Hertogh, Gert
De María, Julio
Del Valle Torrealba Medina, Leyanira
Deliang, Liu
Desreumaux, Pierre
Dewint, Pieter
Ding, Shigang
Doherty, Glen
Draganova, Raina
Dutré, Joris
Duvall, George
Egan, Laurence
Fahed, Julien
Fechner, Lars
Fedurco, Miroslav
Ferhat Celik, Aykut
Fernandez, Juan
Filip, Rafal
Fishman, Sigal
Flores, Cristina
Fogel, Ronald
Fowler, Sharyle
Francesconi, Carlos
Fujii, Toshimitsu
Fujiya, Mikihiro
Fukata, Masayuki
Fukuhara, Seiichiro
Furumoto, Yohei
G.Kiss, Gyula
Gachowski, Waldemar
Gao, Xiang
Gasbarrini, Antonio
Gawdis-wojnarska, Beata
Gaya, Daniel
Geccherle, Andrea
Gilletta De Saint Joseph, Cyrielle
Gimenez, Edgardo
Gionchetti, Paolo
Goldin, Eran
Golovchenko, Oleksandr
Gonciarz, Maciej
Gonen, Can
Gonzales, Chad
Gonzalez, Raquel
Gonzalez Segura, Gaston Julian
Gridnyev, Oleksiy
Gu, Fang
Gupta, Nitin
Gyokeres, Tibor
Haines, Melissa
Hebuterne, Xavier
Hedin, Charlotte
Hellstrom, Per
Hilmi, Ida Normiha
Hirai, Fumihito
Hisabe, Takashi
Hlavaty, Tibor
Hoentjen, Frank
Holtmann, Gerald
Horiki, Noriyuki
Horny, Ivo
Horvat, Gyula
Horvath, Frantisek
Hoshi, Namiko
Hosomi, Shuhei
Hospodarskyy, Ihor
Hou, Xiaohua
Hrdlicka, Ludek
Hu, Naizhong
Huang, Vivian
Huang, Caibin
Inaba, Tomoki
Ishiguro, Yoh
Ishihara, Shunji
Ishikawa, Takeshi
Iskandar, Heba
Israeli, Eran
Itaba, Soichi
Ivanishyn, Olha
Izbéki, Ferenc
Jain, Animesh
Jairath, Vipul
Jang, Byung Ik
Jiang, Chunmeng
Jones, Michael
Kagaya, Takashi
Kalimullina, Dilara
Karakina, Marina
Karatas, Ali
Kashimura, Hiroshi
Keret, Dan
Khovaeva, Yaroslava
Kierkus, Jaroslaw
Kim, Taeoh
Kim, Youngho
Kim, Hyo Jong
Klaus, Jochen
Kleczkowski, Dariusz
Klopocka, Maria
Kobayashi, Taku
Kobielusz-gembala, Iwona
Kojima, Yuichiro
Koo, Ja Seol
Kopon, Adam
Kopp, James
Koyama, Fumikazu
Koynarski, Vasil
Kravchenko, Tetiana
Kudo, Masatoshi
Kusunoki, Ryusaku
Kwon, Kwangan
Laclav, Martin
Lago, Paula
Laharie, David
Lasa, Juan
Lateef, Syed
Latinovic Radakovic, Tatjana
Lee, Kang Moon
Leszczyszyn, Jaroslaw
Li, Yan
Liu, Mei
Liu, Eashen
Lobaton Ortega, Triana
Lopatin, Denis
Lopes, Susana
Lovric Jovanovic, Mileva
Lubini, Marcio
Lukas, Milan
Maaser, Christian
Machytka, Evzen
Maemoto, Atsuo
Magro, Fernando
Marcet, Jorge
Marini, Eduardo
Marusawa, Hiroyuki
Matous, Jan
Matsumoto, Takayuki
Mendu, Shoba
Miao, Yinglei
Mihaly, Emese
Miheller, Pal
Ministro, Paula
Miyabayashi, Hideharu
Mohl, Wolfgang
Molnar, Martin
Moore, Gregory
Moran Faienzo, Gabriela
Morral, Eugeni Domenech
Motoya, Satoshi
Murali, Narayanachar
Mustaffa, Nazri Mohamad
Naem, Mohamed
Nakai, Katsuhiko
Nakajima, Koichi
Nakamoto, Yasunari
Nakamura, Masanao
Nancey, Stephane
Navaneethan, Udayakumar
Nawawi, Khairul Najmi Muhammad
Ninomiya, Tomoyuki
Novak, Janos
Oki, Motoji
Oliveira Santana, Genoile
Onizawa, Michio
Ono, Yohei
Osada, Taro
Osipenko, Marina
Owczarek, Danuta
Parente, Jose Miguel
Patel, Kamal
Patel, Bhaktasharan
Pedersen, Peder
Petroniene, Rima
Petrov, Asen
Petrova, Elina
Piquet, Marie-astrid
Pokrotnieks, Juris
Poroshina, Elena
Portela, Francisco
Pruthi, Jatinder S.
Prystupa, Lyudmila
Pukitis, Aldis
Qiu, Yun
Rafalsky, Vladimir
Rainis, Tova
Ramos Junior, Odery
Rashid, Mohammed
Rayyan, Yasser
Reshetko, Olga
Ribeiro, Tarsila
Rivero, Montserrat
Roblin, Xavier
Romatowski, Jacek
Rowbotham, David
Ruffinengo, Orlando Enrique
Rydzewska-wyszkowska, Grazyna
Sablin, Oleg
Sai, Souken
Saibeni, Simone
Said, Rosaida Hj. Md.
Sakuraba, Hirotake
Samaan, Mark
Sandborn, William
Saruta, Masayuki
Sauk, Jenny
Savarino, Edoardo Vincenzo
Schultz, Michael
Schulze, Joerg
Sedghi, Shahriar
Seidler, Ursula
Seksik, Philippe
Senturk, Omer
Shelton, Edward
Shimizu, Masahito
Shin, Sungjae
Shukla, Richa
Sigal, Michael
Silva Junior, Roberto
Simoes Neto, Joaquim
Siroky Jr., Milan
Smajstrla, Vit
Smid, Vaclav
Smiley, Sarah
Soledad Brunatto, Luciana
Stanislavchuk, Mykola
Stokesberry, David
Stone, Christian
Suiter, Daniel
Suzuki, Takayoshi
Svorcan, Petar
Takagi, Sho
Takagi, Tomohisa
Takamura, Masaaki
Takayama, Tetsuji
Takeuchi, Ken
Tanaka, Akihito
Tanaka, Hiroki
Tanash, Omar
Tang, Wen
Tankova, Ludmila
Teixeira Campos, Luciana
Thin, Lena
Tkachev, Alexander
Tolmanis, Ivars
Tsarynna, Nataliia
Tsonev, Nikolay
Tulassay, Zsolt
Ueo, Tetsuya
Unal, Nalan
Valuyskikh, Ekaterina
Van Dop, Willemijn
Vasilevskaya, Olga
Venugopal, Kannan
Verstockt, Bram
Viamonte, Manuel
Vyshyvanyuk, Vira
Wang, Bangmao
Wang, Xiaoyan
Wang, Jiangbin
Wang, Yufang
Wei, Shu-chen
Weisshof, Roni
Wisam, Sbeit
Wojcik, Katarzyna
Yakovlev, Alexey
Yasuda, Hiroshi
Ye, Byongduk
Yen, Hsu-heng
Yilmaz, Hasan
Yokoyama, Yoko
Yoon, Hyuk
Yoshida, Takeshi
Yurkiv, Andriy
Zaha, Osamu
Zaltman, Cyrla
Zhan, Qiang
Zhang, Hongjie
Zhang, Shutian
Zhu, Lanxiang
Zou, Duowu
Zou, Xiaoping
Zureikat, Firas
Source :
The Lancet; January 2025, Vol. 405 Issue: 10472 p33-49, 17p
Publication Year :
2025

Abstract

Interleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis.

Details

Language :
English
ISSN :
01406736 and 1474547X
Volume :
405
Issue :
10472
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs68479635
Full Text :
https://doi.org/10.1016/S0140-6736(24)01927-5