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Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist
- Source :
- Organic Letters; June 2005, Vol. 7 Issue: 12 p2465-2468, 4p
- Publication Year :
- 2005
-
Abstract
- <UFIGR ID="ol0510062n00002">A stereocontrolled racemic synthesis of conformationally restricted analogues <BO>2a</BO> and <BO>2b</BO> of a potent CGRP receptor antagonist <BO>1</BO> by novel functionalization of 2-substituted octahydropyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted α-nitration of intermediate lactams established the required trans-configuration in the desired products.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 7
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs7316805