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Basic fibroblast growth factor and the complexity of tumour angiogenesis

Authors :
Rak, Janusz
Kerbel, Robert S
Source :
Expert Opinion on Investigational Drugs; May 1998, Vol. 7 Issue: 5 p797-801, 5p
Publication Year :
1998

Abstract

Intrinsic biochemical properties of basic fibroblast growth factor (bFGF) do not adequately explain its potent pro-angiogenic activity. In vivo, bFGF can act in concert with other modulators of angiogenesis, such as vascular endothelial growth factor (VEGF). It is suggested that due to the complexity of angiogenic growth factor networks the process may be regulated in a non-linear fashion.

Details

Language :
English
ISSN :
13543784 and 17447658
Volume :
7
Issue :
5
Database :
Supplemental Index
Journal :
Expert Opinion on Investigational Drugs
Publication Type :
Periodical
Accession number :
ejs7520161
Full Text :
https://doi.org/10.1517/13543784.7.5.797