Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities

Authors :: Ying, C.
Holý, A.
Hocková, D.
Havlas, Z.
De Clercq, E.
Neyts, J.
Source :: Antimicrobial Agents and Chemotherapy; March 2005, Vol. 49 Issue: 3 p1177-1180, 4p
Publication Year :: 2005
Abstract: ABSTRACTNovel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.

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