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Separation of H7-Resistant Protein kinase C Isoforms from Gonadotroph-Derived αT3-1 Cells
- Source :
- Biochemical and Biophysical Research Communications; January 1996, Vol. 218 Issue: 3 p720-725, 6p
- Publication Year :
- 1996
-
Abstract
- Certain physiological events in anterior pituitary tissue are regulated by protein kinase C that is relatively resistant to the inhibitor, H7. In the present studies we have shown that two H7-resistant protein kinase C activities may be isolated from (pituitary) gonadotroph-derived αT3-1 cells using hydroxyapatite chromatography. These activities have the characteristics of PKCζ and an apparently novel PKC isoform. The availability of clonal αT3-1 cells will facilitate investigations of the pituitary events.
Details
- Language :
- English
- ISSN :
- 0006291X and 10902104
- Volume :
- 218
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Biochemical and Biophysical Research Communications
- Publication Type :
- Periodical
- Accession number :
- ejs812482
- Full Text :
- https://doi.org/10.1006/bbrc.1996.0128