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Synthesis of Antimicrobial Natural Products Targeting FtsZ: (±)-Dichamanetin and (±)-2 -Hydroxy-5 -benzylisouvarinol-B
- Source :
- Organic Letters; December 2005, Vol. 7 Issue: 25 p5609-5612, 4p
- Publication Year :
- 2005
-
Abstract
- <UFIGR ID="ol052269zn00001">Two natural products have been synthesized using a ZnCl<INF>2</INF>-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 7
- Issue :
- 25
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs8150755