ERCC1, XPD and RAI mRNA levels in lymphocytes are not associated with lung cancer risk in a prospective study of Danes

Authors :: Vogel, Ulla
Nexø, Bjørn A.
Tjønneland, Anne
Wallin, Håkan
Hertel, Ole
Raaschou-Nielsen, Ole
Source :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; January 2006, Vol. 593 Issue: 1-2 p88-96, 9p
Publication Year :: 2006
Abstract: Low DNA-repair capacity has been associated with increased risk of several types of cancer. mRNA levels of the nucleotide excision repair genes ERCC1 and XPD have been shown to correlate with the DNA-repair capacity. Likewise, mRNA levels of several DNA-repair genes including ERCC1 have been shown to be lower in lymphocytes from patients with lung cancer and head and neck cancer compared with healthy persons. In these studies, the low DNA-repair gene expression levels could be either a risk factor for disease or a consequence of the same.

Language :: English
ISSN :: 13861964
Volume :: 593
Issue :: 1-2
Database :: Supplemental Index
Journal :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publication Type :: Periodical
Accession number :: ejs8308813
Full Text :: https://doi.org/10.1016/j.mrfmmm.2005.06.021

Full Text Access

Tools