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Concentration Effects of Selected Insecticides on Brain Acetylcholinesterase in the Common Carp (Cyprinus carpioL.)
- Source :
- Ecotoxicology and Environmental Safety; January 2000, Vol. 45 Issue: 1 p49-54, 6p
- Publication Year :
- 2000
-
Abstract
- The differential inhibition of acetylcholinesterase (AChE) by organophosphate (OP) and carbamate (C) is followed by the distinct duration of exposure effect on common carp AChE. Hence, in the present study in vivoexposure period effect and in vitroconcentration–response of chlorfenvinphos, chlorpyrifos diazinon, and carbofuran were investigated on Cyprinus carpioL. AChE. Individuals of 1-year-old carp were exposed for 96 h to different concentrations of insecticides, after which AChE activity was measured in the brain. The highest concentrations of carbofuran (2.44 mg·L−1), chlorfenvinphos (2.9 m·L−1), and diazinon (2.5 mg·L−1) killed all the test animals after only 4 h, although there was no statistically significant difference from the control group's brain AChE activity. The lowest concentration significantly inhibited brain AChE after 96 h. Chlorfenvinphos was the most potent inhibitor in vivoand chlorpyrifos the least active inhibitor after 96 h of exposure time. In vitroexperimentation with the same pesticide indicated that several concentrations inhibited 50% of the AChE activity (I50), ranging from 4.1×10−7to 8.12×10−4M in both single inhibitory action and joint inhibitory effect. The results suggest that in biomonitoring programs carp brain AChE can be a good diagnostic tool for chronic OP nd C pollution.
Details
- Language :
- English
- ISSN :
- 01476513 and 10902414
- Volume :
- 45
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Ecotoxicology and Environmental Safety
- Publication Type :
- Periodical
- Accession number :
- ejs838693
- Full Text :
- https://doi.org/10.1006/eesa.1999.1829