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A Comparison Between the Inflammatory Mediators Produced by the Blue-Tongue Lizard (Tiliqua-Scincoides) and Human White Blood-Cells
- Source :
- Australian Journal of Zoology; 1988, Vol. 36 Issue: 2 p209-215, 7p
- Publication Year :
- 1988
-
Abstract
- Human white blood cells, particularly neutrophils and macrophages produce several biologically active molecules including oxygen-derived free radicals and some metabolites of arachidonic acid which are involved in mechanisms of host defence. White blood cells of the blue-tongue lizard Tiliqua scincoides produce certain derivatives of arachidonic acid which include prostaglandins, thromboxane and 12- and 15-hydroxyeicosatetraenoic acid. The ability to produce these compounds indicates that these animals possess the enzymes cyclooxygenase, 12- and 15-lipoxygenase, T. scincoides white blood cells did not produce leukotriene B4 or 5-hydroxyeicosatetraenoic acid indicating that, unlike human white blood cells, they do not possess a 5-lipoxygenase enxyme. T. scincoides cells are also capable of producing the oxygen-derived free radical superoxide enzyme.
Details
- Language :
- English
- ISSN :
- 0004959X
- Volume :
- 36
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Australian Journal of Zoology
- Publication Type :
- Periodical
- Accession number :
- ejs8429079
- Full Text :
- https://doi.org/10.1071/ZO9880209