Back to Search Start Over

A Comparison Between the Inflammatory Mediators Produced by the Blue-Tongue Lizard (Tiliqua-Scincoides) and Human White Blood-Cells

Authors :
Mccoll, SR
Daniels, CB
Source :
Australian Journal of Zoology; 1988, Vol. 36 Issue: 2 p209-215, 7p
Publication Year :
1988

Abstract

Human white blood cells, particularly neutrophils and macrophages produce several biologically active molecules including oxygen-derived free radicals and some metabolites of arachidonic acid which are involved in mechanisms of host defence. White blood cells of the blue-tongue lizard Tiliqua scincoides produce certain derivatives of arachidonic acid which include prostaglandins, thromboxane and 12- and 15-hydroxyeicosatetraenoic acid. The ability to produce these compounds indicates that these animals possess the enzymes cyclooxygenase, 12- and 15-lipoxygenase, T. scincoides white blood cells did not produce leukotriene B4 or 5-hydroxyeicosatetraenoic acid indicating that, unlike human white blood cells, they do not possess a 5-lipoxygenase enxyme. T. scincoides cells are also capable of producing the oxygen-derived free radical superoxide enzyme.

Details

Language :
English
ISSN :
0004959X
Volume :
36
Issue :
2
Database :
Supplemental Index
Journal :
Australian Journal of Zoology
Publication Type :
Periodical
Accession number :
ejs8429079
Full Text :
https://doi.org/10.1071/ZO9880209