Copper(II)-Mediated Cross-Coupling of Arylboronic Acids and 2(1H)-Pyrazinones Facilitated by Microwave Irradiation with Simultaneous Cooling

Optimized conditions for the decoration of the 2(1H)-pyrazinone scaffold were developed by applying the Chan−Lam protocol. It was demonstrated that this Cu(II)-mediated cross-coupling reaction resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling at 0 °C, applying a mixture of bases Et3N/pyridine.