Bromocriptine andamantadine protect against 'naturally occuring' (fracture induced) stress gastric ulcers

It could be argued that many experimental "stress-ulcersinducing methods are not completely related to the naturally occuring circumstances (e.g.restraint stress). Therefore, the influence of dopamine agents bromocriptine (10.o mg/kg b.w.) and amantadine (20.0 mg/kg b.w.) on fracture (metatarsus)-induced gastric lesions was invastigated in rats (Wistar strain, both sexes, 200 g b.w.) Each drug was given i.p. 1 h before injury induction and subsequently once a day. The control animals received an equivolume of saline. The animals were sacrificed 1, 2, 3, 5, 8, 12 and 33 days after injury induction (15 rats for each experimental group) and the stomach examined for presence of lesions as discrabed before (Sikirić et al. , Eur. J. Pharmacol. 1985, 1986, 1987, 1988). Marked gastric lesions were found in the control rats sacrificed 5 (number of lesions per rat 3.7.+0.3, sum of their longest diameters per rat 4.2+-o.1 mm) and 8 (4.0.+-0.2, 4.3+-0.3 mm) days post fracture. No lesionswere noted in treated groups (Student´s t-test vs controls