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SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: frequency and association with inflammatory and tissue-damage biomarkers
- Source :
- JOURNAL OF MEDICAL VIROLOGY, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname
- Publication Year :
- 2022
- Publisher :
- WILEY, 2022.
-
Abstract
- The current study aimed at characterizing the dynamics of SARS-CoV-2 nucleocapsid (N) antigenemia in a cohort of critically ill adult COVID-19 patients and assessing its potential association with plasma levels of biomarkers of clinical severity and mortality. Seventy-three consecutive critically ill COVID-19 patients (median age, 65 years) were recruited. Serial plasma (n=340) specimens were collected. A lateral flow immunochromatography assay and RT-PCR were used for SARS-CoV-2 N protein detection and RNA quantitation and in plasma, respectively. Serum levels of inflammatory and tissue-damage biomarkers in paired specimens were measured. SARS-CoV-RNA N-antigenemia and viral RNAemia were documented in 40.1% and 35.6% of patients, respectively at a median of 9 days since symptoms onset. The level of agreement between the qualitative results returned by the N-antigenemia assay and plasma RT-PCR was moderate (k=0.57; P
- Subjects :
- virus diseases
Subjects
Details
- ISSN :
- 10969071
- Database :
- OpenAIRE
- Journal :
- JOURNAL OF MEDICAL VIROLOGY, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname
- Accession number :
- edsair.RECOLECTA.....cf21d022b2dec64e42f5890a619cf848