Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists

Authors :: Bugatti A
Giagulli C
Urbinati C
Caccuri F
Chiodelli P
Oreste P
Fiorentini S
Orro A
Milanesi L
D'Ursi P
Caruso A
Rusnati M.
Source :: The Journal of biological chemistry, 288 (2013): 1150–1161. doi:10.1074/jbc.M112.400077, info:cnr-pdr/source/autori:Bugatti A, Giagulli C, Urbinati C, Caccuri F, Chiodelli P, Oreste P, Fiorentini S, Orro A, Milanesi L, D'Ursi P, Caruso A, Rusnati M./titolo:Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists./doi:10.1074%2Fjbc.M112.400077/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:1150/pagina_a:1161/intervallo_pagine:1150–1161/volume:288
Publication Year :: 2013
Publisher :: American Society for Biochemistry and Molecular Biology [etc.], [Baltimore, etc.], Stati Uniti d'America, 2013.
Abstract: Background: HIV-1 p17 binds heparin and heparan sulfate proteoglycans of the cell surface. Results: Heparin/p17interactionoccursthroughheparinsulfategroupsandalinearbasicmotifofp17Nterminus,alsoinvolved in p17/CXCR1 interaction. Conclusion: Targeting the basic motif inhibits p17-receptors interaction and consequent biological activities. Significance: Heparin-like molecules represent template for the development of new treatments of p17-dependent/AIDS- associated pathologies.

Language :: English
Database :: OpenAIRE
Journal :: The Journal of biological chemistry, 288 (2013): 1150–1161. doi:10.1074/jbc.M112.400077, info:cnr-pdr/source/autori:Bugatti A, Giagulli C, Urbinati C, Caccuri F, Chiodelli P, Oreste P, Fiorentini S, Orro A, Milanesi L, D'Ursi P, Caruso A, Rusnati M./titolo:Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists./doi:10.1074%2Fjbc.M112.400077/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:1150/pagina_a:1161/intervallo_pagine:1150–1161/volume:288
Accession number :: edsair.cnr...........38891c2402e0e9e91508845b5bff9120
Full Text :: https://doi.org/10.1074/jbc.M112.400077

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