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A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification
- Source :
- Clinica chimica acta, 439 (2015): 49. doi:10.1016/j.cca.2014.10.003., info:cnr-pdr/source/autori:Chiara Fania a,b, Ilaria Sogno c, Michele Vasso d, Enrica Torretta a,b, Roberta Leone a, Antonino Bruno c, Paolo Consonni c, Adriana Albini e, Cecilia Gelfi a,b,f/titolo:A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification./doi:10.1016%2Fj.cca.2014.10.003./rivista:Clinica chimica acta (Print)/anno:2015/pagina_da:49/pagina_a:/intervallo_pagine:49/volume:439
- Publication Year :
- 2015
- Publisher :
- Elsevier, Amsterdam , Paesi Bassi, 2015.
-
Abstract
- BACKGROUND: Prostate cancer (PCa) is the second cause of mortality in men worldwide. The prostate-specific antigen (PSA) test is routinely adopted in diagnosis; nevertheless more reliable biomarkers are continuously under investigation by monitoring the release of molecules into the bloodstream. The serum protein profiles appear to provide cancer-specific fingerprints that help to discriminate patients (especially with low PSA level) from controls, improving the performance of existing clinical tests. METHODS: Samples from healthy controls and PCa patients with low (4ng/mL) levels were analyzed by MALDI profiling, and by a multi fractionation approach coupled to ESI-MS for peaks identification. RESULTS: MALDI profiling achieved to detect 10 and 14 changed peaks (p-value
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clinica chimica acta, 439 (2015): 49. doi:10.1016/j.cca.2014.10.003., info:cnr-pdr/source/autori:Chiara Fania a,b, Ilaria Sogno c, Michele Vasso d, Enrica Torretta a,b, Roberta Leone a, Antonino Bruno c, Paolo Consonni c, Adriana Albini e, Cecilia Gelfi a,b,f/titolo:A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification./doi:10.1016%2Fj.cca.2014.10.003./rivista:Clinica chimica acta (Print)/anno:2015/pagina_da:49/pagina_a:/intervallo_pagine:49/volume:439
- Accession number :
- edsair.cnr...........80078cb5d3bb8e24af75073c0b5e2a9b
- Full Text :
- https://doi.org/10.1016/j.cca.2014.10.003.