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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
- Publication Year :
- 2021
- Publisher :
- Nature Research, 2021.
-
Abstract
- Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
- Subjects :
- hemic and lymphatic diseases
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Accession number :
- edsair.core.ac.uk....1794ecf6a7c4e915d8905f1350b256df