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Rational redox tuning of transition metal sites : Learning from superoxide reductase
- Publication Year :
- 2019
-
Abstract
- Using superoxide reductase as a model system, a computational approach reveals how histidine tautomerism tunes the redox properties of metalloenzymes to enable their catalytic function. Inspired by these experimentally inaccessible insights, non-canonical histidine congeners are introduced as new versatile tools for the rational engineering of biological transition metal sites.
Details
- Language :
- English
- ISSN :
- 1364548X
- Database :
- OpenAIRE
- Accession number :
- edsair.core.ac.uk....7bcf919abe5965258aae34e9bce4c7f9