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Vesicular stomatitis virus An exciting new therapeutic oncolytic virus candidate for cancer or just another chapter from Field's Virology?
- Source :
- Cancer Cell. (4):241-243
- Publisher :
- Cell Press.
-
Abstract
- Selected mutant strains of vesicular stomatitis virus (VSV) are described that are unable to combat endogenous IFN-β signaling within infected normal cells and as a result are dramatically more selective for productive growth in tumor cells having a defective antiviral response. The VSV mutants may have the potential to be used clinically as a systemic oncolytic agent for the treatment of distal and metastatic cancers.
- Subjects :
- viruses
Subjects
Details
- Language :
- English
- ISSN :
- 15356108
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cancer Cell
- Accession number :
- edsair.core.ac.uk....c3dd44c10349df812a0db56d926ced4d
- Full Text :
- https://doi.org/10.1016/S1535-6108(03)00251-4