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Androgen-responsive non-coding small RNAs extend the potential of HCG stimulation to act as a bioassay of androgen sufficiency
- Publication Year :
- 2017
- Publisher :
- BioScientifica, 2017.
-
Abstract
- Background: It is unclear whether a short-term change in circulating androgens is associated with changes in the transcriptome of the peripheral blood mononuclear cells (PBMC).\ud Aims & Methods: To explore the effect of hCG-stimulation on the PBMC-transcriptome, 12 boys with a median age (range) of 0.7yrs (0.3, 11.2) who received intramuscular hCG 1500u on 3 consecutive days as part of their investigations underwent transcriptomic array analysis on RNA extracted from peripheral blood mononuclear cells before and after hCG stimulation.\ud Results: Median pre and post hCG testosterone for the overall group was 0.7nmol/l (
- Subjects :
- endocrine system
Subjects
Details
- Language :
- English
- ISSN :
- 08044643
- Database :
- OpenAIRE
- Accession number :
- edsair.core.ac.uk....cef87baf9518100fe2bb285a0c02f3c2