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Intracytoplasmic sperm injection (ICSI) : the Brussels experience

Authors :
Herman Tournaye
Jiaen Liu
Peter Nagy
Hubert Joris
Arjoko Wisanto
Mary-Louise Bonduelle
Josiane Van Der Elst
Catherine Staessen
Johan Smitz
Sherman Silber
Paul Devroey
Ingeborg Liebaers
Andre Van Steirteghem
Department of Embryology and Genetics
Vrije Universiteit Brussel
Source :
Vrije Universiteit Brussel
Publication Year :
1995
Publisher :
CSIRO, 1995.

Abstract

The present report covers the results of a 26-month period in which 1275 consecutive treatment cycles by intracytoplasmic sperm injection (ICSI) were performed in 919 couples. These couples were afflicted with male factor infertility and had had at least one previous failed conventional in vitro fertilization (IVF) treatment cycle. In other couples, the husband had semen parameters incompatible with conventional IVF or suffered from excretory azoospermia which required microsurgical epididymal sperm aspiration or testicular sperm retrieval. Overall, the 2 pronuclear (PN) fertilization rate was 47.7% per retrieved oocyte-cumulus complex and 66.4% per successfully injected metaphase II oocyte. Embryo transfer was performed in 90.8% of started cycles and 362 clinical pregnancies were recorded, giving a clinical pregnancy rate of 28.4% per started cycle or 31.3% per transfer. In addition, updated results on the outcome of pregnancies after microassisted fertilization are presented. As of 30 August 1994, 416 children have been born. Although 16 major congenital malformations have been observed (3.9%), there appears to be no reason for serious concern as regards the occurrence of major congenital anomalies after ICSI.

Details

Language :
English
Database :
OpenAIRE
Journal :
Vrije Universiteit Brussel
Accession number :
edsair.dedup.wf.001..0c6a286469906e788d6c748000b91f0c