Development of a wireless optical chemical sensor for wound status monitoring

Bežični optički kemijski senzori omogućavaju olakšanu analizu bioloških uzoraka. Neinvazivnost postupka i kontinuirano praćenje u realnom vremenu samo su neke od prednosti nosivih kemijskih senzora u odnosu na klasične laboratorijske instrumente. Idealna primjena takvih senzora je bezbolno praćenje stanja rana. U tu svrhu razvijeno je pH osjetljivo bojilo 4-[4-(2-hidroksietansulfonil)-fenilazo]-2,6-dimetoksifenol, GJM-534, čija konstanta disocijacije odgovara području pH vrijednosti akutnih i kroničnih rana. U radu je provedena spektrofotometrijska karakterizacija imobiliziranog pH osjetljivog bojila na klasični zavoj i poliestersku foliju. Razvijen je pametni zavoj integriranjem imobiliziranog bojila i bežične platforme temeljene na radiofrekvencijskoj identifikaciji (RFID). Ovakva vrsta kemijskih senzora olakšava život oboljelima od kroničnih oblika bolesti koje zahtijevaju kontinuirano praćenje. Wireless optical chemical sensors allow easier analysis of biological samples. Noninvasiveness of the procedure and continuous monitoring in real-time are only some of the advantages of wearable chemical sensors compared to conventional laboratory instruments. An ideal application of such sensors is painless monitoring of wounds. For that purpose it has been developed a pH sensitive dye 4-[4-(2-hydroxyethanesulfonyl)-phenylazo]-2,6-dimethoxyphenol, GJM-534, which has an acid dissociation constant in the range of pH values of acute and chronic wounds. In this work, the spectrophotometric characterization of the immobilized pH sensitive dye on the classic bandage and polyester foil was performed. A smart bandage has been developed by integrating the immobilized dye with a radio-frequency identification (RFID) based wireless platform. This type of sensor improve lives of people suffering from chronic forms of diseases which require continuous monitoring.