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In vivo efficacy of melanoma internal radionuclide therapy with a 131I-labelled melanin-targeting heteroarylcarboxamide molecule
- Source :
- International Journal of Cancer, International Journal of Cancer, Wiley, 2013, 133, pp.1042-1053. ⟨10.1002/ijc.28103⟩, International Journal of Cancer, 2013, 133, pp.1042-1053. ⟨10.1002/ijc.28103⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- The development of alternative therapies for melanoma treatment is of great interest as long-term tumour regression is not achieved with new targeted chemotherapies on selected patients. We previously demonstrated that radioiodinated heteroarylcarboxamide ([131I]ICF01012) induced a strong anti-tumoural effect by inhibiting both primary tumour growth and dissemination process in a B16BL6 melanoma model. In our study, we show that a single injection of [131I]ICF01012 (ranging from 14.8 to 22.2 MBq) was effective and associated with low and transient haematological toxicity. Concerning pigmented organs, cutaneous melanocytes and skin were undamaged. In 30% of treated animals, no histological alteration of retina was observed, and in the remaining 70%, damages were restricted to the optic nerve area. Using the Medical Internal Radiation Dose methodology, we determined that the absorbed dose in major organs is very low (
Details
- Language :
- English
- ISSN :
- 00207136 and 10970215
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer, International Journal of Cancer, Wiley, 2013, 133, pp.1042-1053. ⟨10.1002/ijc.28103⟩, International Journal of Cancer, 2013, 133, pp.1042-1053. ⟨10.1002/ijc.28103⟩
- Accession number :
- edsair.dedup.wf.001..2cfe1ef88c66530ba8d25d42a4e41156