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Short-term hemodynamic effects of apelin in patients with pulmonary arterial hypertension

Authors :
Brash, Lauren
Barnes, Gareth D.
Brewis, Melanie J.
Church, A. Colin
Gibbs, Simon J.
Howard, Luke S.G.E.
Jayasekera, Geeshath
Johnson, Martin K.
McGlinchey, Neil
Onorato, Joelle
Simpson, Joanne
Stirrat, Colin
Thomson, Stephen
Watson, Geoffrey
Wilkins, Martin R.
Xu, Carrie
Welsh, David J.
Newby, David E.
Peacock, Andrew J.
Source :
Brash, L, Barnes, G D, Brewis, M J, Church, A C, Gibbs, S J, Howard, L S G E, Jayasekera, G, Johnson, M K, McGlinchey, N, Onorato, J, Simpson, J, Stirrat, C, Thomson, S, Watson, G, Wilkins, M R, Xu, C, Welsh, D J, Newby, D E & Peacock, A J 2018, ' Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension ', JACC: Basic to Translational Science, vol. 3, no. 2, pp. 176-186 . https://doi.org/10.1016/j.jacbts.2018.01.013
Publication Year :
2018
Publisher :
Elsevier, 2018.

Abstract

Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr1)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr1)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)

Details

Database :
OpenAIRE
Journal :
Brash, L, Barnes, G D, Brewis, M J, Church, A C, Gibbs, S J, Howard, L S G E, Jayasekera, G, Johnson, M K, McGlinchey, N, Onorato, J, Simpson, J, Stirrat, C, Thomson, S, Watson, G, Wilkins, M R, Xu, C, Welsh, D J, Newby, D E & Peacock, A J 2018, ' Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension ', JACC: Basic to Translational Science, vol. 3, no. 2, pp. 176-186 . https://doi.org/10.1016/j.jacbts.2018.01.013
Accession number :
edsair.dedup.wf.001..3729bab86dcc41117757abffd3c14dff
Full Text :
https://doi.org/10.1016/j.jacbts.2018.01.013