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Transancestral mapping and genetic load in systemic lupus erythematosus
- Source :
- Nature communications, vol 8, iss 1
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P
- Subjects :
- Multifactorial Inheritance
American Native Continental Ancestry Group
European Continental Ancestry Group
Black People
Lupus
Autoimmune Disease
White People
Clinical Research
immune system diseases
HLA Antigens
Insertional
Genetics
2.1 Biological and endogenous factors
Humans
Aetiology
Age of Onset
Polymorphism
skin and connective tissue diseases
American Indian or Alaska Native
Sequence Deletion
African Continental Ancestry Group
Lupus Erythematosus
Whites
Inflammatory and immune system
Systemic
Hispanic or Latino
Single Nucleotide
Blacks
Logistic Models
Mutagenesis
Case-Control Studies
Genetic Load
Hispanic Americans
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature communications, vol 8, iss 1
- Accession number :
- edsair.dedup.wf.001..3c213083a4eb4d95b37749d53eb4b85f