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Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases
Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases
- Source :
- Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Journal of Clinical Medicine, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Pseudomonas aeruginosa ( P. aeruginosa ) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of P. aeruginosa over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of "hypermutator P. aeruginosa strain". This phenomenon has been observed in people with bronchiectasis, CF, and the "exacerbator" COPD phenotype. From a clinical point of view, a chronic bronchial infection of P. aeruginosa has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of P. aeruginosa infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.
- Subjects :
- Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]
Diseases::Respiratory Tract Diseases::Bronchial Diseases::Asthma [Medical Subject Headings]
Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa [Medical Subject Headings]
Anatomy::Respiratory System [Medical Subject Headings]
Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial [Medical Subject Headings]
Chronic bronchial infection
Cystic fibrosis
Asthma
Bronchiectasis
respiratory tract diseases
Fibrosis quística
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Diseases::Respiratory Tract Diseases::Lung Diseases::Cystic Fibrosis [Medical Subject Headings]
Bronquiectasia
Pseudomonas aeruginosa
COPD
Enfermedad pulmonar obstructiva crónica
Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]
COPD, Pseudomonas aeruginosa, asthma, bronchiectasis, chronic bronchial infection, cystic fibrosis
Asma
Bronquitis crónica
Diseases::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis [Medical Subject Headings]
Subjects
Details
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Journal of Clinical Medicine, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Accession number :
- edsair.dedup.wf.001..4118a2fed1449c5b490b960fb4ce334a