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Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases

Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases

Authors :
Garcia-Clemente, M
de la Rosa, D
Maiz, L
Giron, R
Blanco, M
Olveira, C
Canton, R
Martinez-Garcia, MA
[Garcia-Clemente,M] Pneumology Department, Hospital Universitario Central de Asturias, Oviedo, Spain. [de la Rosa,D] Pneumology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Máiz,L] Servicio de Neumología, Unidad de Fibrosis Quística, Bronquiectasias e Infección Bronquial Crónica, Hospital Ramón y Cajal, Madrid, Spain. [Girón,R] Pneumology Department, Hospital Univesitario la Princesa, Madrid, Spain. [Blanco,M] Servicio de Neumología, Hospital Universitario A Coruña, A Coruña, Spain. [Olveira,S] Servicio de Neumología, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [Canton,R] Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [Martinez-García,MA] Pneumology Department, Universitary and Polytechnic La Fe Hospital, Valencia, Spain. [Martinez-García,MA] Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Source :
Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Journal of Clinical Medicine, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Pseudomonas aeruginosa ( P. aeruginosa ) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of P. aeruginosa over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of "hypermutator P. aeruginosa strain". This phenomenon has been observed in people with bronchiectasis, CF, and the "exacerbator" COPD phenotype. From a clinical point of view, a chronic bronchial infection of P. aeruginosa has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of P. aeruginosa infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.

Details

ISSN :
20770383
Database :
OpenAIRE
Journal :
Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Journal of Clinical Medicine, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Accession number :
edsair.dedup.wf.001..4118a2fed1449c5b490b960fb4ce334a