HERBAL PRODUCTS AS POTENTIAL THERAPY FOR FUNCTIONAL DYSPEPSIA

Funkcionalna dispepsija (FD) definira se kao prisutnost postprandijalne punine, rane sitosti, epigastričnog žarenjaili boli u odsutnosti druge sistemske, metaboličke ili organske bolesti. FD je podijeljena u sindrom postprandijalnogdistresa (PDS) i sindrom epigastrične boli (EPS) sa značajnim preklapanjem s gastroezofagealnom refluksnom bolesti (GERD) i sindromom iritabilnog crijeva (IBS). Trenutačna preporučena terapija su antisekretorni lijekovi (PPI ili H2RA), no ponavljanje simptoma često je nakon prestanka terapije. Prokinetički lijekovi kao što su metoklopramid i domperidon posebno su djelotvorni u PDS, ali poput antisekretornih lijekova, dugoročna terapija nije preporučljiva. Acotiamid može biti učinkovit kao prokinetik. Antidepresivi (SSRI) pokazuju neke rezultate, kao i bizmutove soli i simetikon, ali su potrebni daljnji adekvatni pokusi i istraživanja. Iz ovog su istraživanja isključeni različiti brojevi kineskih, korejskih i iranskih bilja. Alginati daju učinke u GERB, ali učinci FD-a su upitni. Podaci pokazuju da je SWT5 djelotvoran kao prokinetik, osobito s IBS preklapanjem. Ulje metvice i kima te anisa, ekstrakt lišća đumbira i artičoke imaju bolju učinkovitost od placeba u liječenju funkcionalne dispepsije. Maslinovo ulje, crvena paprika, kurkuma, maslačak i Melissa mogu biti korisni, ali su potrebna dobro razvijena buduća klinička ispitivanja.
Functional dyspepsia (FD) is defined as the presence of postprandial fullness, early satiation, epigastric burning or pain in the absence of other systemic, metabolic or organic disease. FD is divided in post- 3 Sažeci radova / Abstracts prandial distress syndrome (PDS) and epigastric pain syndrome (EPS) with significant overlap with gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) symptoms. Current recommended therapy is antisecretory drugs (PPIs or H2RAs), but recurrence of symptoms is often after intermission of therapy. Prokintetic drugs such as metoclopramide and domperidone are especially effective in PDS, but like antisecretory drugs long term therapy is not recommended. Acotiamide could be effective as prokinetics. Antidepressants (SSRI) show some results as well as bismuth salts and simethicone but adequate trials are needed. Various numbers of Chinese, Korean and Iranian herbs are excluded from this research. Alginates provide effects in GERD, but FD effects are doubtful. Data show that SWT5 is effective as prokinetics, especially with IBS overlap. Peppermint and caraway oil, star anise, ginger and artichoke leaf extracthave better efficacy than placebo in the treatment offunctional dyspepsia. Olive oil, red pepper, curcuma, dandelion and Melissa could be useful, but well developed prospective clinical trials are needed.