Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression

Authors :: Real, Fernando
Capron, Claude
Sennepin, Alexis
Arrigucci, Riccardo
Zhu, Aiwei
Sannier, Gérémy
Zheng, Jonathan
Xu, Lin
Massé, Jean-Marc
Greffe, Ségolène
Cazabat, Michelle
Gennaro, Maria
Rouveix, Elisabeth
Cramer Bordé, Elisabeth
Bomsel, Morgane
[Institut Cochin] Departement Infection, immunité, inflammation
Institut Cochin (IC UM3 (UMR 8104 / U1016))
Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Source :: Sci Transl Med, Sci Transl Med, 2020, 12
Publication Year :: 2020
Publisher :: HAL CCSD, 2020.
Abstract: International audience; In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4 + T cell counts (

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