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Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts
- Source :
- Nimptsch, K, Zhang, X, Cassidy, A, Song, M, O'Reilly, E J, Lin, J H, Pischon, T, Rimm, E B, Willett, W C, Fuchs, C S, Ogino, S, Chan, A T, Giovannucci, E L & Wu, K 2016, ' Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts ', American Journal of Clinical Nutrition, vol. 103, no. 1, pp. 184-191 . https://doi.org/10.3945/ajcn.115.117507
- Publication Year :
- 2016
-
Abstract
- Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one sub-class, flavonols, was significantly associated with reduced risk of recurrent advanced adenoma. Most previous prospective studies on colorectal cancer evaluated only a limited number of flavonoid sub-classes and intake ranges, yielding inconsistent results. Objective: To examine whether higher habitual dietary intakes of flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols and anthocyanins) are associated with lower risk of colorectal cancer. Design: Using data from validated food frequency questionnaires administered every four years and an updated flavonoid food composition database flavonoid intakes were calculated for 42,478 male participants from the Health Professionals Follow-up Study and for 76,364 female participants from the Nurses’ Health Study. Results: During up to 26 years of follow-up, 2,519 colorectal cancer cases (1,061 in men, 1,458 in women) were documented. Intakes of flavonoid subclasses were not associated with risk of colorectal cancer in either cohort. Pooled multivariable adjusted relative risks (95% confidence interval) comparing the highest with the lowest quintile were 1.04 (0.91, 1.18) for flavonols; 1.01 (0.89, 1.15) for flavones; 0.96 (0.84, 1.10) for flavanones; 1.07 (0.95, 1.21) for flavan-3-ols; and 0.98 (0.81, 1.19) for anthocyanins (all p-values for heterogeneity by sex >0.19). In subsite analyses, flavonoid intake was also not associated with colon or rectal cancer risk. Conclusion: Our findings do not support the hypothesis that a higher habitual intake of any flavonoid sub-class decreases the risk of colorectal cancer.
- Subjects :
- Health Professionals Follow-up Study
NSAIDs
AHEI
food frequency questionnaire
food and beverages
colorectal cancer
Nurses’ Health Study
DASH
FFQ
RR
HPFS
CRC
confidence interval
SDG 3 - Good Health and Well-being
nhs
non-steroidal anti-inflammatory drugs
Alternate Healthy Eating Index
Dietary Approaches to Stop Hypertension Score
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nimptsch, K, Zhang, X, Cassidy, A, Song, M, O'Reilly, E J, Lin, J H, Pischon, T, Rimm, E B, Willett, W C, Fuchs, C S, Ogino, S, Chan, A T, Giovannucci, E L & Wu, K 2016, ' Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts ', American Journal of Clinical Nutrition, vol. 103, no. 1, pp. 184-191 . https://doi.org/10.3945/ajcn.115.117507
- Accession number :
- edsair.dedup.wf.001..4d4ad91e3e5844af11d0d61ec49d18f9