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OUR EXPERIENCE IN EXAMINATION ON ANIMAL TUMOR MODELS

OUR EXPERIENCE IN EXAMINATION ON ANIMAL TUMOR MODELS

Authors :
Dusan Lalosevic
ANCA MARIA CIMPEAN
Ivan Capo
Dejan Miljkovic
Milan Popovic
Pavle Banović
Source :
Research and Clinical Medicine, Vol I, Iss Suppl.2, Pp 5-5 (2017), BASE-Bielefeld Academic Search Engine
Publication Year :
2017
Publisher :
Victor Babes University of Medicine and Pharmacy Timisoara, 2017.

Abstract

From the beginning of the 20th Century, scientific interest for animal tumor models has continuously grown. Early works confirmed tumorigenic effect of many animal viruses, parasites, chemicals like tar, smoke and many others. Influences of animal species and their immune status have also a great impact. Our laboratory at the Faculty of Medicine in Novi Sad introduced tumor models in teaching process for students on the bachelor degree and PhD level. We used models as spontaneous tumors in laboratory animals, chemically induced tumors, and transplanted tumors for demonstration of drug effects and some immune mechanisms in tumor biology. From spontaneous tumors we examined micemammary carcinoma, mice lymphoma, hedgehog ovarian carcinoma, and dog prostate hyperplasia. For chemically induction of neoplasia we used 4-NQO in mice and produced squamous carcinoma of the tongue. In the group of transplanted tumors, we used Ehrlich carcinoma in mice and BHK 21C13 sarcoma in diverse species of hamsters and mice. Tested drugs were thalidomide, dexamethason, heparin, metformin, doxorubicin, podoplanin. At this moment, examination of favorable effects of immobilization stress on tumor growth is in progress. Spontaneous and chemically induced tumors need time for growth and their appearance is rare. Because of that, formation of experimental groups is very complicated. We conclude that model of BHK 21C13 cell culture induced sarcoma in Syrian hamsters is the best model, easy reproducible and without influence of host immune mechanisms.

Details

Language :
English
ISSN :
25375393 and 23601124
Database :
OpenAIRE
Journal :
Research and Clinical Medicine
Accession number :
edsair.dedup.wf.001..578ce3913b9dd62b3903f9eae3fc545c