Ocular manifestations of Zika virus: What we do and do not know

Zika virus (ZIKV) disease outbreak, which was declared by the end of 2015 inBrazil, has become the largest one to date. Being reported in the Americas and in certain islands of the Pacific, it has the potential to spread worldwide. Although ZIKV infections are mostly self-limiting and/or asymptomatic in the healthy adult, they are responsible for devastating congenital neurologic malformations ZIKV (mainly microcephaly) when contracted during the first months of pregnancy. Ocular manifestations during the acute adult infection include conjunctivitis and more rarely ocular inflammation. Congenital infection is associated with chorioretinal atrophy pigment mottling of the retina retinal vasculature abnormalities and optic nerve atrophy. Therefore, complete ophthalmological evaluation is recommended for suspected congenital infections. (C) 2017 Elsevier Masson SAS. All rights reserved. Univ Paris Sud, Hop Bicetre, Assistance Publ Hop Paris, Serv Ophtalmol,DHU Vis & Handicap, 78 Rue Gen Leclerc, F-94275 Le Kremlin Bicetre, France Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Paulista Sch Med, Sao Paulo, Brazil Vis Inst, Sao Paulo, Brazil Altino Ventura Fdn, Recife, PE, Brazil Pernambucos Eye Hosp HOPE, Dept Ophthalmol, Recife, PE, Brazil Hosp Geral Roberto Santos, Dept Ophthalmol, Salvador, BA, Brazil Commissariat Energie Atom & Energies Alternat, Immunol Infect Virales & Malad Autoimmunes, UMR 1184, Fontenay Aux Roses, France Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Paulista Sch Med, Sao Paulo, Brazil Web of Science